Urinary Il-33 And Galectin-3 Increases In Patients with Interstitial Cystitis/Bladder Pain Syndrome
Introduction & Objectives: IC/PBS may be mediated by an abnormal immune profile. Uncontrolled and excessive release of alarmins may contributes in the immune dysregulation duringIC/PBS. High mobility group box1 (HMGB1) proteins can participated in pathogenesis of IC/BPC and thus, their analysis in urine of IC/BPC patients may be informative.
Materials & Methods: 43 woman with IC/BPS and 29 women as normal controls were enrolled in this study.. Urinary HMGB1 and EGF concentration was determined . All samples were run in triplicate, and urinary EGF and HMGB1 levels without a consistent value in three measures were repeated and the values were averaged.
Results:Urinary EGF concentration in IC/BPS patients increased significantly as compared to asymptomatic controls, whether expressed as concentration or the amount relative to urine creatinine in each specimen.
Conclusions: Findings indicate that complex changes in the levels of urine HMGB1 are associated with IC/BPS and this group of alarmin may be involved in progression and complications of disease.